A Wake is a character-driven drama told from the point of view of the children in a conservative family as they prepare for the wake of their brother, Mitchel.

Teenage Mason desperately tries to reach Mitchel, his identical twin, through spiritual means. Precocious preteen Molly meticulously organizes the event expecting everything to go exactly as planned. Megan, their older sister, returns home after a long absence, drowning herself both in work and alcohol.

Their Baptist grandmother and parents attempt to maintain normalcy when an unexpected stranger, Jameson, arrives - forcing the family to face secrets and lies around Mitchel's death.